Clinical Guidance

The CDCN works hard to compile useful resources for physicians treating Castleman disease patients and researchers interested in Castleman disease. This resource section contains:

Clinical guidance via CD pages on UpToDate, authored by Dr. David Fajgenbaum, a leading CD researcher in the USA. These pages provide extensive details for all subtypes of CD.
Full text of the diagnostic criteria for idiopathic multicentric Castleman disease, published in Blood, 2017
Full text of the treatment guidelines for idiopathic multicentric Castleman disease, published in Blood, 2018
Full texts of recent and significant CD publications
Compiled evidence for idiopathic multicentric Castleman disease treatment targets
Pathology toolkit describing pathologic features of CD

UpToDate Guidance

Dr. David Fajgenbaum, the leading Castleman disease researcher in the USA, authors all three CD pages on UpToDate. Each page provides extensive information about CD written primarily for physicians treating CD patients. Links to these pages are provided here.

Diagnostic Criteria and Treatment Guidelines

The diagnostic criteria for idiopathic (HHV-8-negative) multicentric Castleman disease–the first-ever diagnostic criteria for CD–was published in the journal Blood in 2017. The full text is available here.

Treatment guidelines for idiopathic (HHV-8-negative) multicentric Castleman disease–the first-ever treatment guidelines for CD–was published in the journal Blood in 2018. The full text is available here.

Research is underway for diagnostic criteria and treatment guidelines for unicentric Castleman disease. This research is being led by Dr. Frits van Rhee at the University of Arkansas for Medical Sciences with significant contributions from Dr. David Fajgenbaum and the CDCN Scientific Advisory Board.

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