Signs & Symptoms

The clinical spectrum of disease severity is very broad, ranging from gradual enlargement of lymph nodes with mild symptoms to sudden, intense onset of symptoms that can cause life-threatening organ dysfunction. Symptoms of Castleman disease often overlap with symptoms of other more common illnesses. A Castleman disease diagnosis can therefore only be made with a lymph node biopsy that shows Castleman disease features and cannot be made by symptoms alone. Common symptoms, among others, include:

  • Flu-like symptoms: fever, night sweats, loss of appetite, nausea, and vomiting
  • Unintended weight loss
  • Weakness and fatigue
  • Enlarged liver or spleen
  • Peripheral neuropathy (numbness in the hands and feet)
  • Cherry hemangioma skin rash
  • Edema (swelling), ascites (fluid accumulation in the abdomen), and/or other symptoms of fluid overload
  • Kidney dysfunction

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