Signs & Symptoms

The clinical spectrum of disease severity is very broad. It ranges from gradual enlargement of lymph nodes with mild symptoms to sudden, intense onset of symptoms that can cause life-threatening organ dysfunction. Symptoms of Castleman disease often overlap with symptoms of many more common illnesses. A Castleman disease diagnosis can only be made with a lymph node biopsy that shows Castleman disease features. The diagnosis cannot be made by symptoms alone. Common symptoms, among others, include:

  • Flu-like symptoms: fever, night sweats, loss of appetite, nausea, and vomiting
  • Unintended weight loss
  • Weakness and fatigue
  • Enlarged liver or spleen
  • Peripheral neuropathy (numbness in the hands and feet)
  • Cherry hemangiomas skin rash
  • Edema (swelling), ascites (fluid accumulation in the abdomen), and/or other symptoms of fluid overload
  • Kidney dysfunction


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