Prognosis

UCD: The average length of survival after UCD diagnosis is greater than 10 years, and life expectancy is usually not changed by UCD.

MCD: The 5-year overall survival rate of HIV negative (presumed HHV8-negative) MCD was 65% in a 2012 case series published prior to the approval of anti-IL-6 therapy (1). There is reasonable hope that the survival rates are currently greatly improved due to the new breakthroughs in treatment (such as anti-IL6 blockade). The CDCN is currently leading a global patient research study to collect data to update these numbers.

  1. Dispenzieri A, Armitage JO, Loe MJ, et al. The clinical spectrum of Castleman’s disease. Am J Hematol. 2012;87(11):997-1002.

 

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