CDCN and COVID-19

CORONA (COvid19 Registry of Off-label & New Agents)

Drug Repurposing for COVID-19

Our overarching vision:  A world where data on all treatments that have been used against COVID19 are maintained in a central repository and analyzed so that physicians currently treating COVID19 patients know what treatments are most likely to help their patients and so that clinical trials can be appropriately prioritized.

Phase 1: COMPLETED

Our team reviewed 2500+ papers & extracted data on over 9,000 COVID19 patients. We found 115 repurposed drugs that have been used to treat COVID19 patients and analyzed data on which ones seem most promising for clinical trials. This data is open source and can be used by physicians to treat patients and prioritize drugs for trials. The CDCN will keep this database updated as a resource for this global fight. Repurposed drugs give us the best chance to help COVID19 as quickly as possible! As disease hunters who have identified and repurposed drugs for Castleman disease, we’re applying our ChasingMyCure approach to COVID19.

A manuscript from Phase I was published by Infectious Diseases & Therapy on May 27, 2020. Click here for the full text of the article.

Phase 2: Continue to update CORONA

Our team continues to work diligently to maintain an updated listing of all treatments reported to be used in COVID19 patients from papers in PubMed.

You can visit the following link to access a database viewer built and managed by Matt Chadsey, owner of Nonlinear Ventures 

Check out the following links for more information about CORONA:

Dr. Fajgenbaum describing the CORONA project on Fresh Air.

Dr. Fajgenbaum describing the CORONA project on 6ABC.

Dr. Fajgenbaum describing the CORONA project on KTLA.

Dr. Fajgenbaum describing the CORONA project on FOX5.

Please email johnson.khor@pennmedicine.upenn.edu if you are interested in contributing to this project by reviewing through published papers and extracting out information about drugs being used to treat COVID19.

Or, if you’d prefer, you can donate to support and enable this critical work at: https://cdcn.org/join-the-fight/donate/

We are grateful to our current team members who have taken on this urgent need:
David Fajgenbaum, CSTL Director
Johnson Khor, CSTL Coordinator and COVID19 Project Lead
Sheila Pierson, CSTL Clinical Research Director
Ruth-Anne Langan, PhD Student and COVID19 Data Analyst
Alek Gorzewski, ACCELERATE Data Analyst and COVID19 Data Analyst
Mileva Repasky, CDCN Chief Patient and Development Officer and COVID19 Data Analyst
Joseph Kakkis, UPenn BS Candidate and COVID19 Data Analyst
Madison McCarthy, Brown University BS Candidate and COVID19 Data Analyst
Anne Taylor, OSU MD Candidate and COVID19 Data Analyst

Erin Napier, University of Hawaii MD Candidate and COVID19 Data Analyst
Lia Keyser, Brown University BA Recipient and COVID19 Data Analyst
Dr. Duncan Mackay, PennMedicine Physician and COVID19 Data Analyst
Alex Beschloss, UPenn MD Candidate and COVID19 Data Analyst
Anna Wing,  UPenn MD Candidate and COVID19 Data Analyst
Ashwin Amurthur,  UPenn MD Candidate and COVID19 Data Analyst
Beatrice Go,  UPenn MD Candidate and COVID19 Data Analyst
Casey Kim,  UPenn MD Candidate and COVID19 Data Analyst
James Germi,  UPenn MD Candidate and COVID19 Data Analyst
Joanna Jiang,  UPenn MD Candidate and COVID19 Data Analyst
Laura Miyarnes,  UPenn MD Candidate and COVID19 Data Analyst
Michael Mayer,  UPenn MD Candidate and COVID19 Data Analyst
Philip Angelides,  UPenn MD Candidate and COVID19 Data Analyst
Sarah Frankl,  UPenn MD Candidate and COVID19 Data Analyst
Vivek Nimgaonkar,  UPenn MD Candidate and COVID19 Data Analyst
Steve Bambury, University of Pittsburg BS Candidate and COVID19 Data Analyst
Nick Goodyear, Temple University BS Candidate and COVID19 Data Analyst