CORONA (COvid19 Registry of Off-label & New Agents)
Drug Repurposing for COVID-19
Our overarching vision: A world where data on all treatments that have been used against COVID19 are maintained in a central repository and analyzed so that physicians currently treating COVID19 patients know what treatments are most likely to help their patients and so that clinical trials can be appropriately prioritized.
Phase 1: COMPLETED
Our team reviewed 2500+ papers & extracted data on over 9,000 COVID19 patients. We found 115 repurposed drugs that have been used to treat COVID19 patients and analyzed data on which ones seem most promising for clinical trials. This data is open source and can be used by physicians to treat patients and prioritize drugs for trials. The CDCN will keep this database updated as a resource for this global fight. Repurposed drugs give us the best chance to help COVID19 as quickly as possible! As disease hunters who have identified and repurposed drugs for Castleman disease, we’re applying our ChasingMyCure approach to COVID19.
Read our systematic literature review published in Infectious Diseases and Therapy at the following link: Treatments Administered to the First 9152 Reported Cases of COVID-19: A Systematic Review
Read the Press Release from PennMedicine at the following link: PennMedicine Press Release
Phase 2: Continue to update CORONA
Our team continues to work diligently to maintain an updated listing of all treatments reported to be used in COVID19 patients from papers in PubMed. We are also re-analyzing publicly available COVID19 single cell transcriptomic data alongside our iMCD data to search for novel insights and therapeutic targets.
You can visit the following link to access a database viewer built and managed by Matt Chadsey, owner of Nonlinear Ventures.
If you are a physician treating COVID19 patients, please visit the FDA’s CURE ID app to report de-identified information about drugs you’ve used to treat COVID19 in just a couple minutes.
Click here for up-to-date treatment guidelines from the NIH.
Check out the following links for more information about CORONA:
Dr. Fajgenbaum describing the CORONA project on Fresh Air.
Dr. Fajgenbaum describing the CORONA project on 6ABC.
Dr. Fajgenbaum describing the CORONA project on KTLA.
Dr. Fajgenbaum describing the CORONA project on FOX5.
Dr. Fajgenbaum describing the CORONA project on ABC7.
CORONA project highlighted in the Boston Globe.
CORONA project highlighted by Diane Sawyer on 20/20.