The Involvement of PI3K-Akt Signaling in the Clinical and Pathological Findings of Idiopathic Multicentric Castleman Disease-Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly and Not Otherwise Specified Subtypes
04/22/2025 Important insight for Castleman disease patients: Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder that is clinically classified into three subtypes: idiopathic plasmacytic lymphadenopathy (IPL); thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO); and not otherwise specified (NOS). The authors clarify the histopathological characteristics of each clinical subtype across 37 patients and perform a whole-transcriptome analysis focusing on angiogenesis-related gene expression. These results suggest that the PI3K-Akt pathway plays an important role in the pathogenesis of TAFRO/NOS subtypes of iMCD.