05/12/2025 Important insight for Castleman disease patients: Individuals diagnosed with Castleman disease (CD) and TAFRO syndrome display a wide range of clinical symptoms. Some patients may present with both CD and TAFRO syndrome concurrently. This retrospective study conducted across multiple centers in Japan examined 321 cases to determine if the quantity and position of swollen lymph nodes could forecast the clinical progression and intensity of these conditions. The study revealed that patients with TAFRO syndrome exhibited lymphadenopathy across all ranges of lymph node region counts. No specific clinical patterns were associated with the number of affected lymph node regions in CD patients, regardless of whether they also had TAFRO syndrome. The results suggest a comprehensive clinical evaluation, rather than relying solely on lymph node count, is crucial for effectively managing these conditions.
